DARE – Deep And REsolved (ANR-21 CEO9)

Partenaires

Laboratoire SYMME

Yannick Mugnier, responsable scientifique, enseignant-chercheur SYMME

Ronan Le-Dantec, enseignant-chercheur SYMME

Émilie Molina, enseignante-chercheuse SYMME

Institut Néel, CNRS, France

Géraldine Dantelle, directrice de recherche

Isabelle Gautier-Luneau, professeure

Valérie Reita, ingénieure de Recherche

Stéphanie Kodjikian, ingénieure de Recherche

Department of Applied Physics, EPFL, Suisse

Sandrine Gerber, professeure

Group of Applied Physics, uni. de Genève, Suisse

Bonacina Luigi, MER

Objectifs

Within the DARE project, we will address the issue of cell tracking in a unified framework, by synthetizing and validating a new generation of multifunctional nanoparticles;(NPs) which will combine multimodal detection capability with on-demand release of drug molecules and in-situ temperature sensing, thanks to the physical. properties of their core structures and the advanced functionalisation of their surfaces. The four main tasks of DARE are the i) synthesis and ii) surface functionalization of multifunctional NPs together with the iii) quantitative assessment of the different contrast efficiencies and drug carrier properties, and iv) benchmarking against the state-of-the-art. An additional feature, which deems essential for any further dissemination and use in (pre)clinical contexts of the multifunctional probes, is the definition and demonstration of a robust upscaling for the synthesis of the nanomaterials selected and perfected during the project.

Résultat(s) / Publications