DARE – Deep And REsolved (ANR-21 CEO9)

Objectifs

Within the DARE project, we will address the issue of cell tracking in a unified framework, by synthetizing and validating a new generation of multifunctional nanoparticles;(NPs) which will combine multimodal detection capability with on-demand release of drug molecules and in-situ temperature sensing, thanks to the physical. properties of their core structures and the advanced functionalisation of their surfaces. The four main tasks of DARE are the i) synthesis and ii) surface functionalization of multifunctional NPs together with the iii) quantitative assessment of the different contrast efficiencies and drug carrier properties, and iv) benchmarking against the state-of-the-art. An additional feature, which deems essential for any further dissemination and use in (pre)clinical contexts of the multifunctional probes, is the definition and demonstration of a robust upscaling for the synthesis of the nanomaterials selected and perfected during the project.

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